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co-branded with ANONAMEDFirst Anaesthetic Guide
Pain & nausea

Comfort is planned in layers

Comfort after surgery is usually planned in layers: local anaesthetic, simple regular analgesia, add-on medicines, and anti-nausea prevention rather than one rescue drug at the end.

Comfort is planned in layers

Pain relief and nausea control

Many first-time patients worry that pain or vomiting will be worse than the operation itself. Good perioperative care usually uses layers of treatment rather than relying on one drug.

Pain is often treated in layers

  • Local anaesthetic infiltration into the wound can reduce pain early.
  • Nerve blocks can provide stronger regional pain relief for selected procedures.
  • Regular paracetamol/acetaminophen is a common foundation.
  • NSAIDs such as ibuprofen or similar may be added if appropriate.
  • Other add-ons can include ketamine, clonidine, tramadol or tapentadol in selected patients.
  • Opioids such as oxycodone may be used when needed; buprenorphine can be given sublingually in some settings.

Important pain reality check

The anaesthetic does not always prevent pain later, because the surgery itself creates tissue injury. What matters is planning for pain rather than pretending it will not happen. Ask what is normal for your specific operation, what you should take regularly, and what the backup plan is if the pain escalates.

Nausea and vomiting

Postoperative nausea and vomiting are common enough that prevention matters, especially if you are prone to motion sickness, are female, do not smoke, have had previous nausea after anaesthesia, or will receive opioid pain relief.

  • Preventive anti-sickness drugs may be given during surgery.
  • Treatments can include ondansetron, metoclopramide, droperidol, cyclizine and others depending on availability and context.
  • Hydration, minimising some triggers and using opioid-sparing pain plans may also help.

Questions worth asking

  • Will I get local anaesthetic or a nerve block?
  • What pain is expected on day 1 and day 2?
  • What should I take regularly at home?
  • What should I do if I cannot keep tablets down?
  • Do I have high nausea risk and will I get prophylaxis?
TopicOften part of the planWhat to remember
PainParacetamol/acetaminophen, NSAID if suitable, local anaesthetic, stronger rescue medication if neededTake regular simple analgesics as directed rather than waiting until pain is severe.
NauseaOndansetron, metoclopramide, droperidol, cyclizine or othersTell the team if you have a strong history of motion sickness or previous PONV.
DrowsinessRest, fluids, supervised recoveryDo not drive, sign important documents or make risky decisions for at least 24 hours.